Publications

2022

Hui M, Beier KT. Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain. Front Mol Neurosci. 2022 Jul 22;15:971349. doi: 10.3389/fnmol.2022.971349. PMID: 35935333; PMCID: PMC9354837. 

Tian G, Hui M, Macchia D, Derdeyn P, Rogers A, Hubbard E, Liu C, Vasquez JJ, Taniguchi L, Bartas K, Carroll S, Beier KT. An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement. Cell Rep. 2022 May 3;39(5):110775. doi: 10.1016/j.celrep.2022.110775. PMID: 35508124; PMCID: PMC9225486.

Derdeyn P, Hui M, Macchia D, Beier KT. Uncovering the Connectivity Logic of the Ventral Tegmental Area. Front Neural Circuits. 2022;15:799688. Published 2022 Jan 28. doi:10.3389/fncir.2021.799688

2021

Rogers A, Beier KT, 2021. Can transsynaptic viral strategies be used to reveal functional aspects of neural circuitry? J Neurosci Methods Jan 15: 348. PDF

Schuster SA, Wagner MJ, Pan-Doh N, Ren J, Grutzner SM, Beier KT, Kim TH, Schnitzer MJ, Luo L. 2021. The relatoinship between birth timing, circuit wiring, and physiological response properties of cerebellar granule cells. PNAS. April 29. doi:10.1073/pnas.2101826118.  PDF

Wu X, Morishita W, Beier KT, Heifets BD, Malenka RC. 5-HT modulation of a medial septal circuit tunes social memory stability. Nature. 2021;599(7883):96-101. doi:10.1038/s41586-021-03956-8

Zhu Z, Hubbard E, Guo X, et al. A connectomic analysis of deep brain stimulation for treatment-resistant depression. Brain Stimul. 2021;14(5):1226-1233. doi:10.1016/j.brs.2021.08.010

Beier KT. The Serendipity of Viral Trans-Neuronal Specificity: More Than Meets the Eye. Front Cell Neurosci. 2021;15:720807. Published 2021 Oct 4. doi:10.3389/fncel.2021.720807

Rogers A, Toledano M, Hubbard E, Macchia D, Hui M, Beier KT. A student-centered seminar course as a complementary approach to a traditional journal club [published online ahead of print, 2021 Nov 18]. Adv Physiol Educ. 2021;10.1152/advan.00145.2021. doi:10.1152/advan.00145.2021

2020

Xu X, Holmes TC, Luo MH, Beier KT, Horwitz GD, Zhao F, Zeng W, Hui M, Semler BL, Sandri-Goldin RM, 2020. Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers. Neuron 107(6):1029-1047. PDF

Steinberg EE, Gore F, Heifets BD, Taylor MD, Norville ZC, Beier KT, Foldy C, Lerner TN, Luo L, Deisseroth K, Malenka RC. Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning. Neuron 106(6): 1026-1043. PDF

Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM, 2020. Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020. 106, 37-65. PDF

2019

Wall NR, Neumann PA, Beier KT, Mokhtari AK, Luo L, Malenka RC, 2019. Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine. Neuron 104(5), 916-930. PDF

Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L, 2019. Synaptic inputs to the mouse dorsal vagal complex and its resident preproglucagon neurons. J Neurosci 39(49): 9767-9781. PDF

Cardozo Pinto DF, Yang H, Dorocic IP, de Jong JW, Han VJ, Peck JR, Liu C, Zhu Y, Beier KT, Smidt MP, Lammel S, 2019. Characterization of transgenic mouse models targeting neuromodulatory systems reveals anatomical and functional heterogeneity of the dorsal raphe nucleus. Nat Communications 10(1):4633. PDF

Beier KT, 2019. Hitchhiking on the neuronal highway: Mechanisms of transsynaptic specificity. Journal of Chemical Neuroanatomy 99: 9-17. PDF

Beier KT, Gao XJ, Xie S, DeLoach KE, Malenka RC, Luo L, 2019. Topological organization of ventral tegmental area connectivity revealed by viral-genetic dissection of input-output relations. Cell Reports 26(1): 159-167.  PDF

2018

Weber F, Do JPH, Chung S, Beier KT, Bikov M, Doost MS, Dan Y, 2018. Regulation of REM and non-REM sleep by periaqueductal GABAergic neurons. Nat Communications 9(1): 354. PDF

Choi K, Holly E, Davatolhagh, Beier KT, Fuccillo MV, 2018. Integrated anatomical and physiological mapping of striatal afferent projections. European Journal of Neuroscience 49(5): 623-636. PDF

2017

Beier KT, Kim CK, Hoerbelt P, Hung LW, Heifets BD, DeLoach KE, Mosca TJ, Neuner S, Deisseroth K, Luo L, Malenka RC, 2017. Rabies screen reveals GPe control of cocaine-triggered plasticity. Nature 549: 345-350. PDF

Hung LW, Neuner S*, Polepalli JS*, Beier KT*, Wright M, Walsh JJ, Lewis EM, Luo L, Deisseroth K, Dolen G, Malenka RC, 2017. Gating of social reward by oxytocin in the ventral tegmental area. Science 357: 1406-1411. (*co-second authors) PDF

Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hormann N, Chang WC, Zhang Z, Do JPH, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, Knight ZA, Luo L, Dan Y, 2017. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature 545: 477-481. PDF

Francois A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Sharif-Naeini R, Deisseroth K, Delp SL, Malenka RC, Luo L, Hantman A, Scherrer GA, 2017. A brainstem – spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins. Neuron 93: 1-18. PDF

2016

Beier KT*, Mundell NA*, Pan YA*, Cepko CL, 2016. Anterograde or retrograde transsynaptic circuit tracing in vertebrates with vesicular stomatitis virus vectors. Curr Protoc Neurosci. Jan 4; 74:1.26.1-1.26.27 (*co-first authors). PDF

2015

Beier KT, Steinberg EE, DeLoach KE, Xie S, Gao XJ, Miyamichi K, Schwarz LA, Kremer EJ, Malenka RC, Luo L, 2015. Circuit architecture of midbrain dopamine neurons revealed by systematic input–output mapping. Cell 162: 622-634. PDF

Lerner TN, Shilyanski CS, Davidson TJ, Evans KE, Beier KT, Zalocusky KA, Crow AK, Malenka RC, Luo L, Tomer R, Deisseroth K, 2015. Independent circuit wiring and information representation within parallel nigrostriatal dopamine circuits revealed with intact-brain structural and functional analysis. Cell 162: 635-647. PDF

Schwarz LA, Miyamichi K, Gao XJ, Beier KT, Weissbourd B, DeLoach KE, Ren J, Ibanes S, Malenka RC, Kremer EJ, Luo L, 2015. Viral-genetic tracing of the input–output organization of a central norepinephrine circuit. Nature 524(7563): 88-92. PDF

Weber F, Chung S, Beier KT, Luo L, Dan Y, 2015. Control of REM sleep by ventral medulla GABAergic neurons. Nature 526(7573): 435-8. PDF

Mundell NA*, Beier KT*, Pan YA*, Lapan SW, Göz Aytürk D, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL, 2015. Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms. J Comp Neurol. 523: 1639-1663 (*co-first authors). PDF

Lammel S, Steinberg EE, Földy C, Wall NR, Beier KT, Luo L, Malenka RC, 2015. Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron 85(2): 429-38. PDF

Nassi JJ, Cepko CL, Born RT, Beier KT, 2015. Neuroanatomy goes viral! Frontiers in Neuroanatomy 9: 80. PDF

Beier KT. Anterograde viral tracer methods. In Axons and Brain Architecture. Academic Press, 2015.

2013

Beier KT, Borghuis B, El-Danaf R, Huberman A, Demb J, Cepko C, 2013. Targeted VSV transsynaptic tracing reveals novel retinal circuitry. J Neurosci 33(1): 35-51. PDF

Beier KT, Saunders A, Oldenburg I, Sabatini B, Cepko C, 2013. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivoFront Neural Circuits 7:11. PDF

Whited JL, Tsai S, Beier KT, White J, Pierkarski N, Hanken J, Cepko C, Tabin CJ, 2013.Pseudotyped retroviruses for infecting axolotl cells ivivo and ivitroDevelopment 140(5): 1137-46. PDF

Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV, 2013. Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library. PLoS One 8(7): e69314. PDF

2012

Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi J, Cepko CL, 2012. Olig2 defines a subpopulation of retinal progenitor cells biased towards specific cell fates. PNAS 109(20): 7882-7. PDF

Beier KT, Cepko C, 2012. Viral tracing of genetically defined neural circuitry. J Vis Exp 68. PDF

2011

Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Ahktar N, Luo L, Whelan S, Sabatini BL, Cepko C, 2011. Anterograde and retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. PNAS 108(37): 15414-9. PDF

Beier KT, Samson MES, Matsuda T, Cepko CL, 2011. Conditional expression of TVA allows clonal analysis of descendants from Cre-expressing progenitor c Dev Biol. 353(2): 309-20. PDF

Cronican JJ, Beier KT, Davis TN, Tseng J, Li W, Brown J, Thompson DB, Shih A, Cepko CL, Kung AL, Zhou Q, Liu DR, 2011. Naturally supercharged human proteins deliver proteins into mammalian cells ivitro and ivivo. Chem Biol 18(7): 833-8. PDF

Beier KT, Eppanapally S, Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB, 2011. Elevation of blood urea nitrogen is predictive of long-term mortality in critically ill patients independent of “normal” creatinine. Crit Care Med 39(2): 305-13. PDF

Tuncdemir SN, Fishell G, 2011. Neural circuits look forward. PNAS 108(39): 16137-8. PDF

2010

Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR, 2010. Potent delivery of functional proteins into mammalian cells in vitro and in vivo using a supercharged p ACS Chem Biol 5(8): 747-52. PDF