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pathological forms of experience-dependent plasticity.

are encoded in the brain to enable both normal and

Our goal is to understand how we learn - how memories

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strategies to better map and manipulate neuronal circuits.

novel molecular reagents, including viral-genetic

Part of the lab will be focused on developing

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neural ensembles is changed in pathological states.

neural substrates of motivated behavior and how activity of these

The other major focus of the lab will be on elucidating the

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The lab will have four major areas of investigation:

1) Elucidating the neural substrates of drug addiction and identifying sources of individual addiction variability
2) Identifying & modulating molecules/circuits that promote behaviors associated with mood disorders such as anxiety and anhedonia
3) Mapping circuit pathology in neurodegenerative conditions such as Parkinson’s and Alzheimers
4) Technology development to further our investigation of biological questions

Recent Publications

Wall NR, Neumann PA, Beier KT, Mokhtari AK, Luo L, Malenka RC, 2019. Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine. Neuron 104(5), 916-930. PDF

Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L, 2019. Synaptic inputs to the mouse dorsal vagal complex and its resident preproglucagon neurons. J Neurosci 39(49): 9767-9781. PDF

Cardozo Pinto DF, Yang H, Dorocic IP, de Jong JW, Han VJ, Peck JR, Liu C, Zhu Y, Beier KT, Smidt MP, Lammel S, 2019. Characterization of transgenic mouse models targeting neuromodulatory systems reveals anatomical and functional heterogeneity of the dorsal raphe nucleus. Nat Communications 10(1):4633. PDF

News

Aly won a UCI Division of Teaching Excellence and Innovation fellowship! So happy to see her efforts be rewarded, she's been doing an amazing job leading our undergraduate lab seminar/discussion course (informally called B-lab 101, now 102). Congrats Aly!!
Katrina Lee Bartas joins us as a graduate student from MCSB! Welcome Katrina!!
Congratulations to lab superstar Pieter for winning a National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) award in the Life Sciences - Artificial Intelligence group! The prestigious award will provide three years of funding for Pieter's exciting work. 🙂 We're proud of you…
Lizzy's poster presentation at the 8th annual Conte Center Symposium won a poster award! Drinks on Lizzy!!!

Upcoming Events

There are no upcoming events at this time.