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pathological forms of experience-dependent plasticity.

are encoded in the brain to enable both normal and

Our goal is to understand how we learn - how memories

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strategies to better map and manipulate neuronal circuits.

novel molecular reagents, including viral-genetic

Part of the lab will be focused on developing

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neural ensembles is changed in pathological states.

neural substrates of motivated behavior and how activity of these

The other major focus of the lab will be on elucidating the

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The lab will have four major areas of investigation:

1) Elucidating the neural substrates of drug addiction and identifying sources of individual addiction variability
2) Identifying & modulating molecules/circuits that promote behaviors associated with mood disorders such as anxiety and anhedonia
3) Mapping circuit pathology in neurodegenerative conditions such as Parkinson’s and Alzheimers
4) Technology development to further our investigation of biological questions

Recent Publications

Wall NR, Neumann PA, Beier KT, Mokhtari AK, Luo L, Malenka RC, 2019. Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine. Neuron 104(5), 916-930. PDF

Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L, 2019. Synaptic inputs to the mouse dorsal vagal complex and its resident preproglucagon neurons. J Neurosci 39(49): 9767-9781. PDF

Cardozo Pinto DF, Yang H, Dorocic IP, de Jong JW, Han VJ, Peck JR, Liu C, Zhu Y, Beier KT, Smidt MP, Lammel S, 2019. Characterization of transgenic mouse models targeting neuromodulatory systems reveals anatomical and functional heterogeneity of the dorsal raphe nucleus. Nat Communications 10(1):4633. PDF

News

Dr. Beier received a UCI Conte Center Seed grant to identify the neural circuits which mediate increased susceptibility to opiate addiction in individuals who experienced early-life adversity: https://contecenter.uci.edu/seed-grant-winners/ Dr. Beier was awarded the NIH New Innovator Award for the project:…
Dr. Beier was awarded the One Mind Rising Stars Award to investigate the neural circuits involved in the development of depression: https://onemind.org/rising-star-awards/ Dr. Beier received a grant from American Parkinson's Disease Association to study circuit-level pathology caused by dopamine depletion:…
Dr. Beier was awarded the Tobacco-Related Diseases Research Program High Impact Pilot Award and the New Investigator Award
Welcome to Alysa Phillips, who has joined the lab as a new graduate student!

Upcoming Events

There are no upcoming events at this time.