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The lab will have four major areas of investigation:

1) Elucidating the neural substrates of drug addiction and identifying sources of individual addiction variability
2) Identifying & modulating molecules/circuits that promote behaviors associated with mood disorders such as anxiety and anhedonia
3) Mapping circuit pathology in neurodegenerative conditions such as Parkinson’s and Alzheimers
4) Technology development to further our investigation of biological questions

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Wall NR, Neumann PA, Beier KT, Mokhtari AK, Luo L, Malenka RC, 2019. Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine. Neuron 104(5), 916-930. PDF
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Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L, 2019. Synaptic inputs to the mouse dorsal vagal complex and its resident preproglucagon neurons. J Neurosci 39(49): 9767-9781. PDF
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Cardozo Pinto DF, Yang H, Dorocic IP, de Jong JW, Han VJ, Peck JR, Liu C, Zhu Y, Beier KT, Smidt MP, Lammel S, 2019. Characterization of transgenic mouse models targeting neuromodulatory systems reveals anatomical and functional heterogeneity of the dorsal raphe nucleus. Nat Communications 10(1):4633. PDF
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