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pathological forms of experience-dependent plasticity.

are encoded in the brain to enable both normal and

Our goal is to understand how we learn - how memories

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strategies to better map and manipulate neuronal circuits.

novel molecular reagents, including viral-genetic

Part of the lab will be focused on developing

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neural ensembles is changed in pathological states.

neural substrates of motivated behavior and how activity of these

The other major focus of the lab will be on elucidating the

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The lab will originally have four areas of investigation:

1) Elucidating the neural substrates of drug addiction and identifying sources of individual addiction variability
2), Identifying & modulating molecules/circuits that promote behaviors associated with mood disorders such as anxiety and anhedonia
3) Mapping circuit pathology in neurodegenerative conditions such as Parkinson’s and Alzheimers
4) Technology development to further our investigation of biological questions

Recent Publications

Primary Research Articles: 1. Beier KT, Gao XJ, Xie S, DeLoach KE, Malenka RC, Luo L, 2019. Topological organization of ventral tegmental area connectivity revealed by viral-genetic dissection of input-output relations. Cell Reports 26(1): 159-167.  PDF 2. Weber F, Do JPH, Chung S, Beier KT, Bikov…


Good luck Desiree! We're rooting for you!
The UCI Public Impact Fellowship Competition was developed to support and highlight academically excellent students whose research demonstrates the potential to significantly improve or enrich the lives of people in California and beyond. Congratulations to Desiree Macchia for being named a Public Impact…

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