January 7th, 2019

Jessica Oshiro, Nina Aghakhani, and Ladan Bigdeli joined the lab as Bio199 students. Welcome Jessica, Nina, and Ladan!

January 2nd, 2019

Our paper systematically mapping inputs to different VTA cell types came out today in Cell Reports! We found that cell types defined by neurochemical phenotype (e.g., Cre line) had no impact on the global inputs those cells received, but the output site of the VTA cells did influence input patterns though spatial localization of those cells in the VTA. Check it out in the publications section.

October 29th, 2018

Mary-Ha Nguyen joined the team as a Student Assistant. Welcome Mary!

October 18th, 2018

Rita Shdid joined the team as a Student Assistant. Welcome Rita!

Primary Research Articles:

1. Beier KT, Gao XJ, Xie S, DeLoach KE, Malenka RC, Luo L, 2019. Topological organization of ventral tegmental area connectivity revealed by viral-genetic dissection of input-output relations. Cell Reports 26(1): 159-167.  PDF

2. Weber F, Do JPH, Chung S, Beier KT, Bikov M, Doost MS, Dan Y, 2018. Regulation of REM and non-REM sleep by periaqueductal GABAergic neurons. Nat Communications 9(1): 354. PDF

3. Choi K, Holly E, Davatolhagh, Beier KT, Fuccillo MV, 2018. Integrated anatomical and physiological mapping of striatal afferent projections. European Journal of Neuroscience doi: 10.1111/ejn.13829. PDF

4. Beier KT, Kim CK, Hoerbelt P, Hung LW, Heifets BD, DeLoach KE, Mosca TJ, Neuner S, Deisseroth K, Luo L, Malenka RC, 2017. Rabies screen reveals GPe control of cocaine-triggered plasticity. Nature 549: 345-350. PDF

5. Hung LW, Neuner S*, Polepalli JS*, Beier KT*, Wright M, Walsh JJ, Lewis EM, Luo L, Deisseroth K, Dolen G, Malenka RC, 2017. Gating of social reward by oxytocin in the ventral tegmental area. Science 357: 1406-1411. (*co-second authors) PDF

6. Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hormann N, Chang WC, Zhang Z, Do JPH, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, Knight ZA, Luo L, Dan Y, 2017. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature 545: 477-481. PDF

7. Francois A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Sharif-Naeini R, Deisseroth K, Delp SL, Malenka RC, Luo L, Hantman A, Scherrer GA, 2017. A brainstem – spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins. Neuron 93: 1-18. PDF

8. Beier KT, Steinberg EE, DeLoach KE, Xie S, Gao XJ, Miyamichi K, Schwarz LA, Kremer EJ, Malenka RC, Luo L, 2015. Circuit architecture of midbrain dopamine neurons revealed by systematic input–output mapping. Cell 162: 622-634. PDF

9. Lerner TN, Shilyanski CS, Davidson TJ, Evans KE, Beier KT, Zalocusky KA, Crow AK, Malenka RC, Luo L, Tomer R, Deisseroth K, 2015. Independent circuit wiring and information representation within parallel nigrostriatal dopamine circuits revealed with intact-brain structural and functional analysis. Cell 162: 635-647. PDF

10. Schwarz LA, Miyamichi K, Gao XJ, Beier KT, Weissbourd B, DeLoach KE, Ren J, Ibanes S, Malenka RC, Kremer EJ, Luo L, 2015. Viral-genetic tracing of the input–output organization of a central norepinephrine circuit. Nature 524(7563): 88-92. PDF

11. Weber F, Chung S, Beier KT, Luo L, Dan Y, 2015. Control of REM sleep by ventral medulla GABAergic neurons. Nature 526(7573): 435-8. PDF

12. Mundell NA*, Beier KT*, Pan YA*, Lapan SW, Göz Aytürk D, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL, 2015. Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms. J Comp Neurol. 523: 1639-1663 (*co-first authors). PDF

13. Lammel S, Steinberg EE, Földy C, Wall NR, Beier KT, Luo L, Malenka RC, 2015. Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron 85(2): 429-38. PDF

14. Beier KT, Borghuis B, El-Danaf R, Huberman A, Demb J, Cepko C, 2013. Targeted VSV transsynaptic tracing reveals novel retinal circuitry. J Neurosci 33(1): 35-51. PDF

15. Beier KT, Saunders A, Oldenburg I, Sabatini B, Cepko C, 2013. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits 7:11. PDF

16. Whited JL, Tsai S, Beier KT, White J, Pierkarski N, Hanken J, Cepko C, Tabin CJ, 2013.Pseudotyped retroviruses for infecting axolotl cells in vivo and in vitro. Development 140(5): 1137-46. PDF

17. Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV, 2013. Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library. PLoS One 8(7): e69314. PDF

18. Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi J, Cepko CL, 2012. Olig2 defines a subpopulation of retinal progenitor cells biased towards specific cell fates. PNAS 109(20): 7882-7. PDF

19. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Ahktar N, Luo L, Whelan S, Sabatini BL, Cepko C, 2011. Anterograde and retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. PNAS 108(37): 15414-9. PDF

20. Beier KT, Samson MES, Matsuda T, Cepko CL, 2011. Conditional expression of TVA allows clonal analysis of descendants from Cre-expressing progenitor c Dev Biol 353(2): 309-20. PDF

21. Cronican JJ, Beier KT, Davis TN, Tseng J, Li W, Brown J, Thompson DB, Shih A, Cepko CL, Kung AL, Zhou Q, Liu DR, 2011. Naturally supercharged human proteins deliver proteins into mammalian cells in vitro and in vivo. Chem Biol 18(7): 833-8. PDF

22. Beier KT, Eppanapally S, Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB, 2011. Elevation of blood urea nitrogen is predictive of long-term mortality in critically ill patients independent of “normal” creatinine. Crit Care Med 39(2): 305-13. PDF

23. Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR, 2010. Potent delivery of functional proteins into mammalian cells in vitro and in vivo using a supercharged p ACS Chem Biol 5(8): 747-52. PDF


Reviews/Protocols/Book Chapters/Commentaries:

1. Botham CM, Arribere JA, Brubaker SW, Beier KT, 2017. Ten simple rules for writing a career development award proposal. PLoS Comput Biol 13(12): e1005863. PDF

2. Beier KT*, Mundell NA*, Pan YA*, Cepko CL, 2016. Anterograde or retrograde transsynaptic circuit tracing in vertebrates with vesicular stomatitis virus vectors. Curr Protoc Neurosci. Jan 4; 74:1.26.1-1.26.27 (*co-first authors). PDF

3. Nassi JJ, Cepko CL, Born RT, Beier KT, 2015. Neuroanatomy goes viral! Frontiers in Neuroanatomy 9: 80. PDF

4. Beier KT. Anterograde viral tracer methods. In Axons and Brain Architecture. Academic Press, 2015.

5. Beier KT, Cepko C, 2012. Viral tracing of genetically defined neural circuitry. J Vis Exp 68. PDF

6. Tuncdemir SN,Fishell G, 2011. Neural circuits look forward. PNAS 108(39): 16137-8. PDF