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pathological forms of experience-dependent plasticity.

are encoded in the brain to enable both normal and

Our goal is to understand how we learn - how memories

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strategies to better map and manipulate neuronal circuits.

novel molecular reagents, including viral-genetic

Part of the lab will be focused on developing

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neural ensembles is changed in pathological states.

neural substrates of motivated behavior and how activity of these

The other major focus of the lab will be on elucidating the

The lab will have four major areas of investigation:

1) Elucidating the neural substrates of drug addiction and identifying sources of individual addiction variability
2) Identifying & modulating molecules/circuits that promote behaviors associated with mood disorders such as anxiety and anhedonia
3) Mapping circuit pathology in neurodegenerative conditions such as Parkinson’s and Alzheimers
4) Technology development to further our investigation of biological questions

Recent Publications

Beier KT, Gao XJ, Xie S, DeLoach KE, Malenka RC, Luo L, 2019. Topological organization of ventral tegmental area connectivity revealed by viral-genetic dissection of input-output relations. Cell Reports 26(1): 159-167.  PDF

Weber F, Do JPH, Chung S, Beier KT, Bikov M, Doost MS, Dan Y, 2018. Regulation of REM and non-REM sleep by periaqueductal GABAergic neurons. Nat Communications9(1): 354. PDF

Choi K, Holly E, Davatolhagh, Beier KT, Fuccillo MV, 2018. Integrated anatomical and physiological mapping of striatal afferent projections. European Journal of Neuroscience doi: 10.1111/ejn.13829. PDF

News

April 2019 Guilian Tian, Sean Carroll, Jessica Park, Nora Ayache, and Anthony Tran joined the lab. 
Check out the press release of our most recent article published in Cell Reports: https://www.eurekalert.org/pub_releases/2019-01/uoc--usr012419.php
January 7th, 2019 Jessica Oshiro, Nina Aghakhani, and Ladan Bigdeli joined the lab as Bio199 students. Welcome Jessica, Nina, and Ladan!
January 2nd, 2019 Our paper systematically mapping inputs to different VTA cell types came out today in Cell Reports! We found that cell types defined by neurochemical phenotype (e.g., Cre line) had no impact on the global inputs those cells received, but the output site of the VTA cells did influence…

Upcoming Events

There are no upcoming events at this time.
 
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